The research adds that “The lack of psychoactivity associated with cannabidiol allows it to be administered in higher doses than would be possible with psychotropic cannabinoids such as THC. Furthermore, the ability of cannabidiol to protect against neuronal injury without inhibiting NMDAr may reduce the occurrence of toxicity or side effects associated with NMDAr antagonists. Previous studies have indicated that cannabidiol is not toxic, even when chronically administered to humans (or given in large acute doses [700 mg/day), “via NCBI
The above research demonstrates that even when cannabinoids free of THC are given in higher doses like 700mg/day to humans, there are no toxic side effects.
CBD has been proven to help reduce cell damage that occurs from free radicals. That said, cannabidiol oil (CBD) can help dogs with skin allergies, inflammation, itchy skin, and also help promote a healthy coat and skin in dogs. “Cannabidiol, THC, and BHT all prevented dihydroergotamine oxidation in a similar, concentration-dependent manner indicating cannabinoids to be comparable to BHT in antioxidant potency,” NCBI.
The study adds that “The antioxidative properties of cannabinoids suggest a therapeutic use as neuroprotective agents, and the particular properties of cannabidiol make it a good candidate for such development. Although cannabidiol was similar in neuroprotective capacity to BHT, cannabidiol has no known tumor-promoting effects. The lack of psychoactivity associated with cannabidiol allows it to be administered in higher doses than would be possible with psychotropic cannabinoids such as THC.”
Healing out pets naturally with full-spectrum hemp CBD oil tinctures, treats, salves, and chews instead of Benadryl may reduce the chances of side effects or toxicity associated with Benadryl overdoses in pets. There are also certain health conditions that may prevent you from using Benadryl on your dogs such as severe heart failure, seizure disorders, bladder neck obstructions, pregnancies, allergic lung disease and even hypertension. As usual, it’s always best to consult with your veterinarian for the best advice.